%0 Figure %A Yamada, Hidetoshi %A Kikuchi, Sayaka %A Inui, Tomoki %A Takahashi, Hideyuki %A Kimura, Ken-ichi %D 2014 %T MeOH extract from gentian roots inhibits LPS-induced TNF-α production. %U https://plos.figshare.com/articles/figure/_MeOH_extract_from_gentian_roots_inhibits_LPS_induced_TNF_945_production_/1251348 %R 10.1371/journal.pone.0113834.g001 %2 https://plos.figshare.com/ndownloader/files/1806400 %K lps %K Murine Macrophages BackgroundGentian roots %K inhibition %K compound %K RAW 264.7 cells %K inos %K extract %K mrna %K gentiolactone %K expression %K Gentiana triflora %K nf %K mechanism %K cox %K tnf %K gentian roots %X

RAW264.7 cells were cultured for 4 hours with LPS (100 ng/mL) and 0.1, 0.5, 2.5 or 12.5 mg/mL MeOH extract (A), or 60, 300 or 1500 µM swertiamarin or gentiopicroside (B). TNF-α mRNA levels were measured by real-time PCR. Plotted values represent the mean value ± SD from four independent cultures. *p<0.05, **p<0.01.

%I PLOS ONE