Kang, Yu-Lin Ahson Saleem, Moin Wah Chan, Kwok Yat-Ming Yung, Benjamin Ka-Wai Law, Helen Trehalose induced podocyte autophagy in an mTOR independent manner. <p>mTOR activity was not altered in trehalose-treated podocytes. Podocytes were treated with trehalose (50 mM) for 0, 12, 24, 36, 48 and 60 h. The phosphorylation level of p-mTOR (<b>A</b>) and its substrates p-p70S6K (<b>B</b>) and p-4E-BP1 (<b>C</b>) were measured by Western blotting, nā€Š=ā€Š5, 5 and 6 respectively. However, no significant changes were observed. The representative immunoblot was shown along with the statistical results.</p> Alleviates Human Podocyte Injury;Puromycin Aminonucleoside Treatment Glomerular diseases;reactive oxygen species involvement;attenuate podocyte injury;Lactate dehydrogenase activity;autophagy;mTOR Independent Autophagy Inducer;Podocyte apoptosis;change nephrotic syndrome;podocyte injury;trehalose;actin cytoskeleton rearrangement;LC 3 puncta 2014-11-20
    https://plos.figshare.com/articles/figure/_Trehalose_induced_podocyte_autophagy_in_an_mTOR_independent_manner_/1247862
10.1371/journal.pone.0113520.g002