10.1371/journal.pgen.1008586.g007
Takeshi Moriishi
Takeshi
Moriishi
Ryosuke Ozasa
Ryosuke
Ozasa
Takuya Ishimoto
Takuya
Ishimoto
Takayoshi Nakano
Takayoshi
Nakano
Tomoka Hasegawa
Tomoka
Hasegawa
Toshihiro Miyazaki
Toshihiro
Miyazaki
Wenguang Liu
Wenguang
Liu
Ryo Fukuyama
Ryo
Fukuyama
Yuying Wang
Yuying
Wang
Hisato Komori
Hisato
Komori
Xin Qin
Xin
Qin
Norio Amizuka
Norio
Amizuka
Toshihisa Komori
Toshihisa
Komori
Crystallite size in the BAp <i>c</i>-axis and Young’s modulus in femurs of female wild-type and Ocn<sup>–/–</sup>mice at 9 months of age.
Public Library of Science
2020
Ocn
strength
BAp
testosterone synthesis
collagen fibrils
muscle mass
crystallite
bone quantity
glucose metabolism
2020-05-28 17:25:12
Figure
https://plos.figshare.com/articles/figure/Crystallite_size_in_the_BAp_i_c_i_-axis_and_Young_s_modulus_in_femurs_of_female_wild-type_and_Ocn_sup__sup_mice_at_9_months_of_age_/12384443
<p>(A) The crystallite size in the BAp <i>c</i>-axis in the longitudinal and vertical directions at position 5. (B) Young’s modulus along the bone longitudinal axis at position 5 in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008586#pgen.1008586.g006" target="_blank">Fig 6A</a> as measured by nanoindentation. **: P<0.01. X symbols in box plots show outliers. (C) Single regression analysis of Young’s modulus to BMD and each degree of the preferential alignment of collagen fibers and the BAp <i>c</i>-axis in the bone longitudinal direction at position 5. wt: blue dots, Ocn<sup>–/–</sup>: red dots. wt: n = 5, Ocn<sup>–/–</sup>: n = 6. (D) Schematic presentation of orientations of collagen fibrils and BAp <i>c</i>-axis. In wild-type mice, the orientations of collagen fibrils and BAp <i>c</i>-axis are parallel to the bone longitudinal axis. In Ocn<sup>–/–</sup>mice, the orientation of collagen fibrils is parallel to the bone longitudinal axis, whereas that of BAp <i>c</i>-axis is severely disrupted from the longitudinal axis. The disruption of the BAp <i>c</i>-axis orientation reduces Young’s modulus in the longitudinal axis.</p>