10.1371/journal.pgen.1008586.g007 Takeshi Moriishi Takeshi Moriishi Ryosuke Ozasa Ryosuke Ozasa Takuya Ishimoto Takuya Ishimoto Takayoshi Nakano Takayoshi Nakano Tomoka Hasegawa Tomoka Hasegawa Toshihiro Miyazaki Toshihiro Miyazaki Wenguang Liu Wenguang Liu Ryo Fukuyama Ryo Fukuyama Yuying Wang Yuying Wang Hisato Komori Hisato Komori Xin Qin Xin Qin Norio Amizuka Norio Amizuka Toshihisa Komori Toshihisa Komori Crystallite size in the BAp <i>c</i>-axis and Young’s modulus in femurs of female wild-type and Ocn<sup>–/–</sup>mice at 9 months of age. Public Library of Science 2020 Ocn strength BAp testosterone synthesis collagen fibrils muscle mass crystallite bone quantity glucose metabolism 2020-05-28 17:25:12 Figure https://plos.figshare.com/articles/figure/Crystallite_size_in_the_BAp_i_c_i_-axis_and_Young_s_modulus_in_femurs_of_female_wild-type_and_Ocn_sup__sup_mice_at_9_months_of_age_/12384443 <p>(A) The crystallite size in the BAp <i>c</i>-axis in the longitudinal and vertical directions at position 5. (B) Young’s modulus along the bone longitudinal axis at position 5 in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008586#pgen.1008586.g006" target="_blank">Fig 6A</a> as measured by nanoindentation. **: P<0.01. X symbols in box plots show outliers. (C) Single regression analysis of Young’s modulus to BMD and each degree of the preferential alignment of collagen fibers and the BAp <i>c</i>-axis in the bone longitudinal direction at position 5. wt: blue dots, Ocn<sup>–/–</sup>: red dots. wt: n = 5, Ocn<sup>–/–</sup>: n = 6. (D) Schematic presentation of orientations of collagen fibrils and BAp <i>c</i>-axis. In wild-type mice, the orientations of collagen fibrils and BAp <i>c</i>-axis are parallel to the bone longitudinal axis. In Ocn<sup>–/–</sup>mice, the orientation of collagen fibrils is parallel to the bone longitudinal axis, whereas that of BAp <i>c</i>-axis is severely disrupted from the longitudinal axis. The disruption of the BAp <i>c</i>-axis orientation reduces Young’s modulus in the longitudinal axis.</p>