10.1371/journal.ppat.1004487.g003
Dawoon Chung
Dawoon
Chung
Bridget M. Barker
Bridget
M. Barker
Charles C. Carey
Charles
C. Carey
Brittney Merriman
Brittney
Merriman
Ernst R. Werner
Ernst R.
Werner
Beatrix E. Lechner
Beatrix
E. Lechner
Sourabh Dhingra
Sourabh
Dhingra
Chao Cheng
Chao
Cheng
Wenjie Xu
Wenjie
Xu
Sara J. Blosser
Sara
J. Blosser
Kengo Morohashi
Kengo
Morohashi
Aurélien Mazurie
Aurélien
Mazurie
Thomas K. Mitchell
Thomas
K. Mitchell
Hubertus Haas
Hubertus
Haas
Aaron P. Mitchell
Aaron
P. Mitchell
Robert A. Cramer
Robert
A. Cramer
Temporal transcriptional induction of SrbA and SrbB in response to Hypoxia Reveals SrbB transcript levels are induced prior to SrbA.
Public Library of Science
2014
hypoxia
ipa
infection site adaptation
SrbA target gene
heme biosynthesis
hypoxic conditions accounts
infection site pathobiology
Aspergillus fumigatus SREBP SrbA
element binding protein
Fungal Hypoxia Response
dna
Vivo Transcriptome Analyses
SrbB
virulence
Aspergillus fumigatus sterol
antifungal drug resistance
SrbA transcriptional regulation
2014-11-06 03:46:06
Figure
https://plos.figshare.com/articles/figure/_Temporal_transcriptional_induction_of_SrbA_and_SrbB_in_response_to_Hypoxia_Reveals_SrbB_transcript_levels_are_induced_prior_to_SrbA_/1230879
<p><i>Aspergillus fumigatus</i> wild type was cultured in normoxia at 37°C for 18 hours and shifted to hypoxia for additional incubation for 5, 15, and 30 minutes. Data are presented as the mean and standard error of three biological replicates. Compared to normoxia (Hyp 0′), <i>srbB</i> expression was significantly induced in hypoxia 15 min, which was earlier than the initial <i>srbA</i> induction. The data were analyzed by two-way ANOVA followed by Bonferroni posttests.</p>