10.1371/journal.ppat.1004487.g003 Dawoon Chung Dawoon Chung Bridget M. Barker Bridget M. Barker Charles C. Carey Charles C. Carey Brittney Merriman Brittney Merriman Ernst R. Werner Ernst R. Werner Beatrix E. Lechner Beatrix E. Lechner Sourabh Dhingra Sourabh Dhingra Chao Cheng Chao Cheng Wenjie Xu Wenjie Xu Sara J. Blosser Sara J. Blosser Kengo Morohashi Kengo Morohashi Aurélien Mazurie Aurélien Mazurie Thomas K. Mitchell Thomas K. Mitchell Hubertus Haas Hubertus Haas Aaron P. Mitchell Aaron P. Mitchell Robert A. Cramer Robert A. Cramer Temporal transcriptional induction of SrbA and SrbB in response to Hypoxia Reveals SrbB transcript levels are induced prior to SrbA. Public Library of Science 2014 hypoxia ipa infection site adaptation SrbA target gene heme biosynthesis hypoxic conditions accounts infection site pathobiology Aspergillus fumigatus SREBP SrbA element binding protein Fungal Hypoxia Response dna Vivo Transcriptome Analyses SrbB virulence Aspergillus fumigatus sterol antifungal drug resistance SrbA transcriptional regulation 2014-11-06 03:46:06 Figure https://plos.figshare.com/articles/figure/_Temporal_transcriptional_induction_of_SrbA_and_SrbB_in_response_to_Hypoxia_Reveals_SrbB_transcript_levels_are_induced_prior_to_SrbA_/1230879 <p><i>Aspergillus fumigatus</i> wild type was cultured in normoxia at 37°C for 18 hours and shifted to hypoxia for additional incubation for 5, 15, and 30 minutes. Data are presented as the mean and standard error of three biological replicates. Compared to normoxia (Hyp 0′), <i>srbB</i> expression was significantly induced in hypoxia 15 min, which was earlier than the initial <i>srbA</i> induction. The data were analyzed by two-way ANOVA followed by Bonferroni posttests.</p>