10.1371/journal.pone.0111550.g005
Alessandra Fazzini
Alessandra
Fazzini
Vanessa D’Antongiovanni
Vanessa
D’Antongiovanni
Laura Giusti
Laura
Giusti
Ylenia Da Valle
Ylenia
Da Valle
Federica Ciregia
Federica
Ciregia
Ilaria Piano
Ilaria
Piano
Antonella Caputo
Antonella
Caputo
Anna Maria D’Ursi
Anna Maria
D’Ursi
Claudia Gargini
Claudia
Gargini
Antonio Lucacchini
Antonio
Lucacchini
Maria Rosa Mazzoni
Maria
Rosa Mazzoni
PAR<sub>1</sub> agonist-induced G<sub>12/13</sub> signaling is impaired in NCI-H28 cells.
Public Library of Science
2014
plasma membrane localization
mesothelioma cell lines
dysfunctional PAR 1
Malignant Pleural Mesothelioma Cell Line
mesothelioma REN cells
PAR 1
cell surface PAR 1 expression
2014-11-03 03:53:37
Figure
https://plos.figshare.com/articles/figure/_PAR_1_agonist_induced_G_12_13_signaling_is_impaired_in_NCI_H28_cells_/1227677
<p>A, relative levels of RhoA activation in response to thrombin in Met-5A and NCI-H28 cells. B, relative levels of RhoA activation in response to the selective PAR<sub>1</sub>-AP in Met-5A and NCI-H28 cells. Rho A activation was measured in serum and growth factor starved cells using the RhoA G-LISA kit from Cytoskeleton. Data shown are mean ± SEM of three independent experiments performed in triplicate. The differences in RhoA activation between Ctrl (vehicle treated Met-5A or NCI-H28 cells) and agonist-treated cells were significant (*P≤0.05, **P≤0.01, ***P≤0.001) by one-way ANOVA followed by Bonferroni’s multiple comparison test (n = 3).</p>