Determination of 50% mouse lethal dose (LD<sub>50</sub>).
Jang-Hoon Choi
Hye-Min Woo
Tae-young Lee
So-young Lee
Sang-Mu Shim
Woo-Jung Park
Jeong-Sun Yang
Joo Ae Kim
Mi-Ran Yun
Dae-Won Kim
Sung Soon Kim
Yi Zhang
Wei Shi
Lingshu Wang
Barney S. Graham
John R. Mascola
Nanshuang Wang
Jason S. McLellan
Joo-Yeon Lee
Hansaem Lee
10.1371/journal.pone.0232757.s002
https://plos.figshare.com/articles/figure/Determination_of_50_mouse_lethal_dose_LD_sub_50_sub_/12274418
<p>(A) Body weight loss curve of 10-week-old male C57BL/6N-hDPP4 mice (n = 5 per group) infected with different doses of MERS-CoV KNIH-002. The error bar indicate the standard error of the mean. The weight loss and survival were monitored for 14 days.</p> <p>(TIF)</p>
2020-05-08 17:30:46
syndrome coronavirus Middle East
prefusion-stabilized spike protein
B cells
receptor-binding domain
RBD-specific antibodies
PBMC
syndrome coronavirus
S 1
IC
prefusion MERS-CoV S probe
KNIH 90-F
neutralizing potency
DPP 4
antibody