Identification of Novel Markers of Mouse Fetal Ovary Development
Huijun Chen
James S. Palmer
Rathi D. Thiagarajan
Marcel E. Dinger
Emmanuelle Lesieur
Hansheng Chiu
Alexandra Schulz
Cassy Spiller
Sean M. Grimmond
Melissa H. Little
Peter Koopman
Dagmar Wilhelm
10.1371/journal.pone.0041683
https://plos.figshare.com/articles/dataset/Identification_of_Novel_Markers_of_Mouse_Fetal_Ovary_Development/122276
<div><p>In contrast to the developing testis, molecular pathways driving fetal ovarian development have been difficult to characterise. To date no single master regulator of ovarian development has been identified that would be considered the female equivalent of <em>Sry</em>. Using a genomic approach we identified a number of novel protein-coding as well as non-coding genes that were detectable at higher levels in the ovary compared to testis during early mouse gonad development. We were able to cluster these ovarian genes into different temporal expression categories. Of note, <em>Lrrc34</em> and <em>AK015184</em> were detected in XX but not XY germ cells before the onset of sex-specific germ cell differentiation marked by entry into meiosis in an ovary and mitotic arrest in a testis. We also defined distinct spatial expression domains of somatic cell genes in the developing ovary. Our data expands the set of markers of early mouse ovary differentiation and identifies a classification of early ovarian genes, thus providing additional avenues with which to dissect this process.</p> </div>
2012-07-26 00:37:56
markers
fetal
ovary