C. Rocha, Sayonarah T. C. Pessoa, Marco D. R. Neves, Luiza L. G. Alves, Silmara Silva, Luciana M. L. Santos, Herica M. F. Oliveira, Soraya G. Taranto, Alex Comar, Moacyr V. Gomes, Isabella V. Santos, Fabio Paixão, Natasha E. M. Quintas, Luis Noël, François F. Pereira, Antonio C. S. C. Tessis, Ana L. S. Gomes, Natalia C. Moreira, Otacilio Rincon-Heredia, Ruth P. Varotti, Fernando Blanco, Gustavo A. F. P. Villar, Jose G. Contreras, Rubén A. Barbosa, Leandro High concentrations of 21-BD reduce cell viability of HeLa and RKO. <p>HeLa (A) or RKO (B) cells were treated with digoxin (green symbols) or 21-BD (red symbols) for 24 (circles) or 48 (squares) h. Viability was measured by MTT reduction assay. 100 and 25 µM 21-BD induced the statistically significant reduction of HeLa and RKO viability, respectively (p<0.0084). Digoxin reduces HeLa viability starting with 150 µM for 24 h and 50 µM for 48 h (p<0.001). RKO cells have a higher sensitivity to digoxin that induces statistically significant differences starting from 1.6 µM for 48 h (p<0.0001).</p> bd;Junctions Cardiotonic steroids;RKO cancer cells;na;cardiotonic;modulates epithelial cell adhesion;db;multidrug exporter Pdr 5p;digoxin;epithelial MDCK cells;lactone ring 2014-10-07
    https://plos.figshare.com/articles/figure/_High_concentrations_of_21_BD_reduce_cell_viability_of_HeLa_and_RKO_/1196750
10.1371/journal.pone.0108776.g004