10.1371/journal.pone.0108776.g004
Sayonarah C. Rocha
Sayonarah
C. Rocha
Marco T. C. Pessoa
Marco
T. C. Pessoa
Luiza D. R. Neves
Luiza
D. R. Neves
Silmara L. G. Alves
Silmara
L. G. Alves
Luciana M. Silva
Luciana M.
Silva
Herica L. Santos
Herica
L. Santos
Soraya M. F. Oliveira
Soraya
M. F. Oliveira
Alex G. Taranto
Alex
G. Taranto
Moacyr Comar
Moacyr
Comar
Isabella V. Gomes
Isabella
V. Gomes
Fabio V. Santos
Fabio
V. Santos
Natasha Paixão
Natasha
Paixão
Luis E. M. Quintas
Luis
E. M. Quintas
François Noël
François
Noël
Antonio F. Pereira
Antonio
F. Pereira
Ana C. S. C. Tessis
Ana
C. S. C. Tessis
Natalia L. S. Gomes
Natalia
L. S. Gomes
Otacilio C. Moreira
Otacilio
C. Moreira
Ruth Rincon-Heredia
Ruth
Rincon-Heredia
Fernando P. Varotti
Fernando
P. Varotti
Gustavo Blanco
Gustavo
Blanco
Jose A. F. P. Villar
Jose
A. F. P. Villar
Rubén G. Contreras
Rubén
G. Contreras
Leandro A. Barbosa
Leandro
A. Barbosa
High concentrations of 21-BD reduce cell viability of HeLa and RKO.
Public Library of Science
2014
bd
Junctions Cardiotonic steroids
RKO cancer cells
na
cardiotonic
modulates epithelial cell adhesion
db
multidrug exporter Pdr 5p
digoxin
epithelial MDCK cells
lactone ring
2014-10-07 03:18:49
Figure
https://plos.figshare.com/articles/figure/_High_concentrations_of_21_BD_reduce_cell_viability_of_HeLa_and_RKO_/1196750
<p>HeLa (A) or RKO (B) cells were treated with digoxin (green symbols) or 21-BD (red symbols) for 24 (circles) or 48 (squares) h. Viability was measured by MTT reduction assay. 100 and 25 µM 21-BD induced the statistically significant reduction of HeLa and RKO viability, respectively (p<0.0084). Digoxin reduces HeLa viability starting with 150 µM for 24 h and 50 µM for 48 h (p<0.001). RKO cells have a higher sensitivity to digoxin that induces statistically significant differences starting from 1.6 µM for 48 h (p<0.0001).</p>