10.1371/journal.pone.0108399.g001 Christina L. Nemeth Christina L. Nemeth Erica R. Glasper Erica R. Glasper Constance S. Harrell Constance S. Harrell Sanjana A. Malviya Sanjana A. Malviya Jeffrey S. Otis Jeffrey S. Otis Gretchen N. Neigh Gretchen N. Neigh Rats were assessed in a battery of behavioral tests of depressive- and anxiety-like behaviors. Public Library of Science 2014 Meloxicam Blocks Neuroinflammation drug abuse behaviors haart hippocampal cell proliferation hippocampu expression cox monocyte chemotactic protein adolescent HIV Daily meloxicam treatments 2014-10-01 02:51:53 Figure https://plos.figshare.com/articles/figure/_Rats_were_assessed_in_a_battery_of_behavioral_tests_of_depressive_and_anxiety_like_behaviors_/1189610 <p><i>A,B</i>) In the forced swim test, latency to first immobile bout was not different between WT and HIV-1 tg rats (<i>p</i>>0.05); but HIV-1 tg rats spent significantly more time immobile in the test relative to WT controls. To measure social interaction, WT and HIV-1 tg rats were presented with an age-matched stimulus conspecific and allowed to interact for 10 minutes. <i>C,D</i>) HIV-1 tg rats had a greater latency to approach the stimulus animal (*<i>p</i><0.05) and spent less total time interacting, relative to WT controls. The open field paradigm was used to assess anxiety-like behaviors over a 10 minute period. Total distance traveled as well as distance traveled in the center was recorded. <i>E</i>) Total activity was unchanged between WT and HIV-1 tg rats as measured in 75 cm×75 cm arena during the open field test (<i>p</i>>0.05). <i>F</i>) Compared to WT controls, HIV-1 tg rats showed decreased activity in the center of the open field suggestive of increased anxiety-like behavior. For all, *<i>p</i><0.05 and data are presented as mean ± SEM.</p>