Endothelial cell activation and stress in the liver and lungs.
Lynn Soong
Hui Wang
Thomas R. Shelite
Yuejin Liang
Nicole L. Mendell
Jiaren Sun
Bin Gong
Gustavo A. Valbuena
Donald H. Bouyer
David H. Walker
10.1371/journal.pntd.0003191.g007
https://plos.figshare.com/articles/figure/_Endothelial_cell_activation_and_stress_in_the_liver_and_lungs_/1182377
<p>Mice (4–5/group) were inoculated with <i>O. tsutsugamushi</i> Karp stain, as described in <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003191#pntd-0003191-g001" target="_blank"><b><i>Fig. 1</i></b></a>. Liver and lung tissues were collected at 0, 2, 6, and 10 dpi and analyzed via qRT-PCR for gene expression. (<b>A, C</b>) Data are shown as mean ± SEM in each group and are presented as “relative mRNA level” (after normalization to the housekeeping genes). (<b>B, D</b>) The Ang-2/Ang-1 ratios of individual samples were calculated based on the corresponding data in <b>A</b> and <b>C</b>. *, <i>p</i><0.05; **, <i>p</i><0.01.</p>
2014-09-25 03:27:48
typhus
disease pathogenesis
inoculated C 57BL mice
alteration
murine model
obligately intracellular
ifn
ror
gata
tsutsugamushi infection
mpo
cxcr
cxcl
Orientia tsutsugamushi
animal death
Growth factors
tissue damage
tnf
il