Endothelial cell activation and stress in the liver and lungs. Lynn Soong Hui Wang Thomas R. Shelite Yuejin Liang Nicole L. Mendell Jiaren Sun Bin Gong Gustavo A. Valbuena Donald H. Bouyer David H. Walker 10.1371/journal.pntd.0003191.g007 https://plos.figshare.com/articles/figure/_Endothelial_cell_activation_and_stress_in_the_liver_and_lungs_/1182377 <p>Mice (4–5/group) were inoculated with <i>O. tsutsugamushi</i> Karp stain, as described in <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003191#pntd-0003191-g001" target="_blank"><b><i>Fig. 1</i></b></a>. Liver and lung tissues were collected at 0, 2, 6, and 10 dpi and analyzed via qRT-PCR for gene expression. (<b>A, C</b>) Data are shown as mean ± SEM in each group and are presented as “relative mRNA level” (after normalization to the housekeeping genes). (<b>B, D</b>) The Ang-2/Ang-1 ratios of individual samples were calculated based on the corresponding data in <b>A</b> and <b>C</b>. *, <i>p</i><0.05; **, <i>p</i><0.01.</p> 2014-09-25 03:27:48 typhus disease pathogenesis inoculated C 57BL mice alteration murine model obligately intracellular ifn ror gata tsutsugamushi infection mpo cxcr cxcl Orientia tsutsugamushi animal death Growth factors tissue damage tnf il