10.1371/journal.pone.0108138.g001
Kathryn A. Radigan
Kathryn
A. Radigan
Luisa Morales-Nebreda
Luisa
Morales-Nebreda
Saul Soberanes
Saul
Soberanes
Trevor Nicholson
Trevor
Nicholson
Recep Nigdelioglu
Recep
Nigdelioglu
Takugo Cho
Takugo
Cho
Monica Chi
Monica
Chi
Robert B. Hamanaka
Robert
B. Hamanaka
Alexander V. Misharin
Alexander
V. Misharin
Harris Perlman
Harris
Perlman
G. R. Scott Budinger
G.
R. Scott Budinger
Gökhan M. Mutlu
Gökhan
M. Mutlu
Effect of leptin receptor function on the survival, the degree of lung injury and inflammation during influenza A infection.
Public Library of Science
2014
influenza
mortality
leptin receptor
leptin receptor deficiency
alveolar type II cells
infection
leptin receptor results
Leptin Receptor Deficient Mice
H 1N outbreak
lung epithelial cells
lung injury severity.ResultsThe clearance
2014-09-18 02:43:23
Figure
https://plos.figshare.com/articles/figure/_Effect_of_leptin_receptor_function_on_the_survival_the_degree_of_lung_injury_and_inflammation_during_influenza_A_infection_/1173388
<p><i>db/db</i> and C57BL/6 mice were inoculated with influenza A virus (A/WSN/33 [H1N1]) <b>(a)</b> 1500 pfu/mouse or <b>(b)</b> 500 pfu/mouse and mortality was subsequently assessed on a daily basis. Percentage of weight loss was also followed daily for the mice infected with <b>(c)</b> 1500 pfu/mouse or <b>(d)</b> 500 pfu/mouse. Four days after infection with influenza A virus 1500 pfu/mouse, <i>db/db</i> and C57BL/6 mice underwent a bronchoalveolar lavage for <b>(e</b>) assessment of cell count, <b>(f)</b> total protein, <b>(g,h)</b> inflammatory cytokines, <b>(i)</b> flow cytometry, and <b>(j)</b> the assessment of lung pathology (Hematoxylin and Eosin staining). * p<0.05 compared to PBS control. ** p<0.05 <i>db/db</i> compared to wild-type mice.</p>