Dose-response plot of <i>Y. pestis</i> growth as a function of FR900098 concentration.
Amanda Haymond
Chinchu Johny
Tyrone Dowdy
Brandon Schweibenz
Karen Villarroel
Richard Young
Clark J. Mantooth
Trishal Patel
Jessica Bases
Geraldine San Jose
Emily R. Jackson
Cynthia S. Dowd
Robin D. Couch
10.1371/journal.pone.0106243.g002
https://plos.figshare.com/articles/figure/_Dose_response_plot_of_Y_pestis_growth_as_a_function_of_FR900098_concentration_/1155772
<p>Fractional growth is calculated as the ratio of cell density (OD<sub>600</sub>) in the presence of inhibitor to cell density in the absence of inhibitor. Nonlinear regression fitting was performed, resulting in an IC<sub>50</sub> of 29 µM (6.4 µg/mL). The goodness-of-fit (R<sup>2</sup>) value is indicated. For comparison, the IC<sub>50</sub> of ampicillin is 10.8 µM (3.8 µg/mL; see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0106243#pone.0106243.s001" target="_blank">Figure S1</a>).</p>
2014-08-29 02:58:51
KMNADPH
product allosteric affector
FR 900098
KMDXP
drug development
DXP binding sites
IC 50 values
MEP pathway
methylerythritol phosphate
pestis MEP synthase
pilot scale library
nadph
MEP synthase
nm
novel antibiotic development