Body weight and water consumption are not affected by LM11A-31 treatment in Tg2576 mice. Danielle A. Simmons Juliet K. Knowles Nadia P. Belichenko Gargi Banerjee Carly Finkle Stephen M. Massa Frank M. Longo 10.1371/journal.pone.0102136.g003 https://plos.figshare.com/articles/figure/_Body_weight_and_water_consumption_are_not_affected_by_LM11A_31_treatment_in_Tg2576_mice_/1150743 <p>(<b><i>A</i></b>) Body weight of 17 month old female Tg2576 mice treated with LM11A-31 for 3 months (nTg-Veh, n = 7 mice; Tg2576-Veh, n = 6; Tg2576-31, n = 5; nTg–LM11A-31, n = 4). Starting at treatment week 6, Tg2576 mice weighed less than WT mice; LM11A-31 had no effect on this measure. Statistical significance was determined using repeated measures ANOVA with Dunnett's post-hoc test. (<b><i>B</i></b>) Average grams of water consumed by Tg2576 mice over 3 days was significantly greater than nTg mice; LM11A-31 had no effect on this measure. Statistical significance was determined using two-tailed Student's t-test. *p≤0.05 vs. nTg Veh.</p> 2014-08-25 08:51:16 basal forebrain cholinergic neurons basal forebrain levels AD mouse models cholinergic neurites dystrophic neurites molecule p 75NTR ligands 1 month LM 11A treatment cholinergic neurite atrophy modulating p 75NTR Small Molecule p 75NTR Ligand LM 11A Reverses Cholinergic Neurite Dystrophy p 75NTR appl AD mouse model LM 11A neurotrophin receptor p 75 pathology basal forebrain cholinergic neurites p 75NTR ligand Disease Mouse Models Tg 2576 mice