Hanford, Lindsay C. Eckstrand, Kristen Manelis, Anna Hafeman, Danella M. Merranko, John Ladouceur, Cecile D. Graur, Simona McCaffrey, Alicia Monk, Kelly Bonar, Lisa K. Hickey, Mary Beth Goldstein, Tina R. Goldstein, Benjamin I. Axelson, David Bebko, Genna Bertocci, Michele A. Gill, Mary Kay Birmaher, Boris Phillips, Mary L. Interaction effects of risk calculator score and negative stressful life events schedule (nSLES) score on whole-brain functional connectivity to bilateral amygdala during emotion processing (top). <p>Positive interactions between risk calculator score, nSLES score and activity were found within 2 clusters after correction for multiple comparisons. A graphical representation of this interaction in the right lateral occipital cortex is presented here (bottom). Higher risk calculator score showed a greater positive association between functional connectivity and nSLES score, which was not present at low risk calculator score. A full set of these interaction plots can be found in the supplementary. * au = arbitrary units All results were corrected for using Z-statistic threshold at z>2.3, pFWE<0.0017. A contrast of all emotions versus shape conditions was used. Functional connectivity values were mean adjusted using a healthy control sample.</p> BD;risk calculator scores;life adversity;reward processing networks;reward processing task;bipolar disorder;OBP;Risk calculator score;reward processing tasks;factors influence emotion;SLES;Stressful Life Events Schedule;emotion processing task;youth 2019-12-12
    https://plos.figshare.com/articles/figure/Interaction_effects_of_risk_calculator_score_and_negative_stressful_life_events_schedule_nSLES_score_on_whole-brain_functional_connectivity_to_bilateral_amygdala_during_emotion_processing_top_/11362049
10.1371/journal.pone.0226135.g002