Interaction effects of risk calculator score and negative stressful life events schedule (nSLES) score on whole-brain activity during emotion processing (top). Lindsay C. Hanford Kristen Eckstrand Anna Manelis Danella M. Hafeman John Merranko Cecile D. Ladouceur Simona Graur Alicia McCaffrey Kelly Monk Lisa K. Bonar Mary Beth Hickey Tina R. Goldstein Benjamin I. Goldstein David Axelson Genna Bebko Michele A. Bertocci Mary Kay Gill Boris Birmaher Mary L. Phillips 10.1371/journal.pone.0226135.g001 https://plos.figshare.com/articles/figure/Interaction_effects_of_risk_calculator_score_and_negative_stressful_life_events_schedule_nSLES_score_on_whole-brain_activity_during_emotion_processing_top_/11362043 <p>Positive interactions between risk calculator score, nSLES score and activity were found within 3 clusters after correction for multiple comparisons. A graphical representation of this interaction in the right fusiform gyri is presented here (bottom). Higher risk calculator score showed a greater positive association between activity and nSLES score. A full set of these interaction plots can be found in the supplementary. * au = arbitrary units All results were corrected for using Z-statistic threshold at z>2.3, pFWE<0.0017. A contrast of all emotions versus shape conditions was used. Activity values were mean adjusted using a healthy control sample.</p> 2019-12-12 18:46:30 BD risk calculator scores life adversity reward processing networks reward processing task bipolar disorder OBP Risk calculator score reward processing tasks factors influence emotion SLES Stressful Life Events Schedule emotion processing task youth