10.1371/journal.pone.0226135.g001 Lindsay C. Hanford Lindsay C. Hanford Kristen Eckstrand Kristen Eckstrand Anna Manelis Anna Manelis Danella M. Hafeman Danella M. Hafeman John Merranko John Merranko Cecile D. Ladouceur Cecile D. Ladouceur Simona Graur Simona Graur Alicia McCaffrey Alicia McCaffrey Kelly Monk Kelly Monk Lisa K. Bonar Lisa K. Bonar Mary Beth Hickey Mary Beth Hickey Tina R. Goldstein Tina R. Goldstein Benjamin I. Goldstein Benjamin I. Goldstein David Axelson David Axelson Genna Bebko Genna Bebko Michele A. Bertocci Michele A. Bertocci Mary Kay Gill Mary Kay Gill Boris Birmaher Boris Birmaher Mary L. Phillips Mary L. Phillips Interaction effects of risk calculator score and negative stressful life events schedule (nSLES) score on whole-brain activity during emotion processing (top). Public Library of Science 2019 BD risk calculator scores life adversity reward processing networks reward processing task bipolar disorder OBP Risk calculator score reward processing tasks factors influence emotion SLES Stressful Life Events Schedule emotion processing task youth 2019-12-12 18:46:30 Figure https://plos.figshare.com/articles/figure/Interaction_effects_of_risk_calculator_score_and_negative_stressful_life_events_schedule_nSLES_score_on_whole-brain_activity_during_emotion_processing_top_/11362043 <p>Positive interactions between risk calculator score, nSLES score and activity were found within 3 clusters after correction for multiple comparisons. A graphical representation of this interaction in the right fusiform gyri is presented here (bottom). Higher risk calculator score showed a greater positive association between activity and nSLES score. A full set of these interaction plots can be found in the supplementary. * au = arbitrary units All results were corrected for using Z-statistic threshold at z>2.3, pFWE<0.0017. A contrast of all emotions versus shape conditions was used. Activity values were mean adjusted using a healthy control sample.</p>