Neuronal interactions involving cocaine- and amphetamine-regulated transcript (CART)-containing kisspeptin (KP), neurokinin B (NKB) and substance P (SP) neurons in the infundibular nucleus (Inf). Katalin Skrapits Beáta Á. Borsay László Herczeg Philippe Ciofi Stephen R. Bloom Mohammad A. Ghatei Waljit S. Dhillo Zsolt Liposits Erik Hrabovszky 10.1371/journal.pone.0103977.g004 https://plos.figshare.com/articles/figure/_Neuronal_interactions_involving_cocaine_and_amphetamine_regulated_transcript_CART_containing_kisspeptin_KP_neurokinin_B_NKB_and_substance_P_SP_neurons_in_the_infundibular_nucleus_Inf_/1125040 <p>Neuropeptides exhibit variable colocalization patterns in neuronal cell bodies and fibers of the Inf (see color-coded captions). Single-, double- and triple-labeled peptidergic axons establish appositions onto other peptidergic neurons. Such appositions often involve CART-IR neuronal elements. The CART/KP/NKB triple-labeled cell body in <b>A</b> and <b>B</b> receives an axo-somatic afferent contact from a single-labeled CART-IR axon (green arrow in <b>B</b>). The CART/KP double-labeled cell body in <b>C</b> and <b>D</b> receives an afferent contact from a KP/NKB double-IR axon (purple arrows in <b>D</b>). A CART/SP double-IR neuron in <b>E</b> is innervated by KP-IR (red arrows) and KP/SP double-IR (purple arrow) axons. The dendrite of a GnRH neuron (brown pseudocolor) in <b>F</b> receives innervation from a CART/KP/NKB-IR triple-phenotype axon (white arrow). Scale bars = 20 µm in <b>A</b>, <b>C</b>, 12 µm in <b>E</b> and 10 µm in <b>B</b>, <b>D</b> and <b>F</b>.</p> 2014-08-01 03:41:18 anatomy Reproductive system Biochemistry Neurochemistry Neuroendocrinology neuroscience physiology Physiological processes Sexual reproduction interactions involving cocaine- amphetamine-regulated transcript kisspeptin neurokinin neurons infundibular nucleus