%0 Figure %A Young Lee, Eun %A Soo Kim, Sang %A Lee, Ji-Sung %A Joo Kim, In %A Heon Song, Sang %A Cha, Seung-Kuy %A Park, Kyu-Sang %A Suk Kang, Jeong %A Hee Chung, Choon %D 2014 %T Plasma (A,B) and urine (C,D) levels of soluble α-klotho in normal participants (n = 25) and patients with type 2 diabetes (n = 147). %U https://plos.figshare.com/articles/figure/_Plasma_A_B_and_urine_C_D_levels_of_soluble_klotho_in_normal_participants_n_25_and_patients_with_type_2_diabetes_n_147_/1124685 %R 10.1371/journal.pone.0102984.g001 %2 https://plos.figshare.com/ndownloader/files/1618517 %K Bioassays and physiological analysis %K Biochemical analysis %K Clinical chemistry %K Diagnostic medicine %K Endocrinology %K Nephrology %K Pathology and laboratory medicine %K Clinical pathology %K urine %K soluble %K patients %X

Plasma and urine α-klotho levels were higher in diabetes patients with relatively preserved renal function than the non-diabetic controls (A,C). The diabetes patients were categorized into 3 groups according to urine ACR: ACR <30 mg/g creatinine (normoalbuminuria group, n = 75), ACR 30–299 mg/g creatinine (microalbuminuria group, n = 42), and ACR ≥300 mg/g creatinine (macroalbuminuria group, n = 30). Plasma α-klotho levels decreased in proportion to urinary albumin excretion, although urinary α-klotho levels were stable with increasing urinary albumin excretion (B,D). Data of non-diabetic control are expressed as a shaded area for the reference (B, D). Data are presented as geometric means and 95% CIs as an error bar plot. P-values calculated using the log-transformed values are shown in the graph. normo; normoalbuminuria, micro; microalbuminuria, macro; macroalbuminuria.

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