Hennessy, Emma O'Callaghan, Julie J. Mooij, Marlies Legendre, Claire Camacho-Vanegas, Olga C. Camacho, Sandra Adams, Claire A. Martignetti, John O'Gara, Fergal Statin treatment and <i>P. aeruginosa</i> infection modulate the host immune response. <p>A549 cells were treated with 10 µM simvastatin or an equivalent amount of DMSO (VEHICLE) for 24 hours. Untreated and statin-treated cells were subsequently infected with <i>P. aeruginosa</i> PAO1 for 3 hours at MOI 50∶1. The expression of (<b>A</b>) KLF2 (<b>B</b>) KLF6 (<b>C</b>) IL-8 (<b>D</b>) CCL20 and (<b>E</b>) TLR5 was analysed in uninfected cells, and in the presence of vehicle, simvastatin (SIM), <i>P. aeruginosa</i> (PAO1) and simvastatin and PAO1 combined (SIM+PAO1). *<i>P</i>, ≤0.05, **<i>P</i>, ≤0.01, ***<i>P</i>, ≤0.001.</p> cell biology;Molecular cell biology;genetics;gene expression;immunology;Immune response;inflammation;Immune system;Innate immune system;immunity;Immune activation;microbiology;bacteriology;Gram negative bacteria;Medical microbiology;Microbial pathogens;Bacterial pathogens;Infectious diseases;Bacterial diseases;Pseudomonas infections;Pathology and laboratory medicine;pathogenesis;Host-pathogen interactions;modulate 2014-07-10
    https://plos.figshare.com/articles/figure/_Statin_treatment_and_P_aeruginosa_infection_modulate_the_host_immune_response_/1099267
10.1371/journal.pone.0102200.g001