Zhang, Ting-ting Liu, Dong Calabro, Samuele C. Eisenbarth, Stephanie Cattoretti, Giorgio M. Haberman, Ann LPS-induced rapid reduction of BCL6 levels does not occur in MyD88<sup>−/−</sup> TRIF<sup>−/−</sup> mice. <p>WT or MyD88<sup>−/−</sup> TRIF<sup>−/−</sup> mice were <i>i.p.</i> injected with LPS. <i>(A)</i> Representative FACS plots (n = 4) showing CD11c and I-A/E expression on splenic cells in 0 h or 24 h post-LPS injected mice. <i>(B)</i> and <i>(C)</i> The MFI±SEM (n = 4) of CD11c <i>(B)</i> and CD86 <i>(C)</i> in gated splenic CD11c<sup>int</sup> I-A<sup>hi</sup> cells obtained from either WT or MyD88<sup>−/−</sup> TRIF<sup>−/−</sup> mice 0 h (black bar) or 24 h after (grey bar) LPS injection. <i>(D)</i> and <i>(E)</i> The average MFI ±SEM (n = 4) of BCL6 in CD11c<sup>hi</sup> I-A<sup>int </sup><i>(D)</i> and CD11c<sup>int</sup> I-A<sup>hi </sup><i>(E)</i> cells 0 h (black bar) and 24 h after (grey bar) LPS injection. ***<i>p</i><0.001 (two way ANOVA) was compared within each group.</p> Biochemistry;proteomics;Protein abundance;cell biology;Cellular types;Animal cells;Immune cells;Antigen-presenting cells;Bone marrow cells;Molecular cell biology;developmental biology;Cell differentiation;immunology;Immune system;Innate immune system;immunity;Model organisms;Animal models;Mouse models;bcl6 2014-06-30
    https://plos.figshare.com/articles/figure/_LPS_induced_rapid_reduction_of_BCL6_levels_does_not_occur_in_MyD88_8722_8722_TRIF_8722_8722_mice_/1088635
10.1371/journal.pone.0101208.g007