Co-inheritance of α-thalassemia among patients and controls.
Maryam Bibi Rumaney
Valentina Josiane Ngo Bitoungui
Anna Alvera Vorster
Raj Ramesar
Andre Pascal Kengne
Jeanne Ngogang
Ambroise Wonkam
10.1371/journal.pone.0100516.g001
https://plos.figshare.com/articles/figure/_Co_inheritance_of_945_thalassemia_among_patients_and_controls_/1088622
<p><b>Panel A</b> displays a much higher prevalence of 3.7α-globin gene deletions among patients compared to unaffected controls [HbAA and HbSS combined (p = 0.003)]. This difference was mostly driven by a much lower proportion of 3.7 kb α-globin gene deletions among HbAA controls. <b>Panel B</b> displays the allele frequencies of the 3.7 kb α-globin gene deletions among patient and control. The frequencies were 22% among patients and 11.8% among controls (HbAS and HbAA combined) (p = 0.006). HbAS controls had more 3.7 kb α-globin gene deletions than HbAA controls (p = 0.02).</p>
2014-06-30 02:57:52
anatomy
Body fluids
blood
genetics
Human genetics
hematology
Hemoglobinopathies
Tropical diseases
patients