Co-inheritance of α-thalassemia among patients and controls. Maryam Bibi Rumaney Valentina Josiane Ngo Bitoungui Anna Alvera Vorster Raj Ramesar Andre Pascal Kengne Jeanne Ngogang Ambroise Wonkam 10.1371/journal.pone.0100516.g001 https://plos.figshare.com/articles/figure/_Co_inheritance_of_945_thalassemia_among_patients_and_controls_/1088622 <p><b>Panel A</b> displays a much higher prevalence of 3.7α-globin gene deletions among patients compared to unaffected controls [HbAA and HbSS combined (p = 0.003)]. This difference was mostly driven by a much lower proportion of 3.7 kb α-globin gene deletions among HbAA controls. <b>Panel B</b> displays the allele frequencies of the 3.7 kb α-globin gene deletions among patient and control. The frequencies were 22% among patients and 11.8% among controls (HbAS and HbAA combined) (p = 0.006). HbAS controls had more 3.7 kb α-globin gene deletions than HbAA controls (p = 0.02).</p> 2014-06-30 02:57:52 anatomy Body fluids blood genetics Human genetics hematology Hemoglobinopathies Tropical diseases patients