10.1371/journal.pone.0100325.g003 Gregory J. Babcock Gregory J. Babcock Sowmya Iyer Sowmya Iyer Heidi L. Smith Heidi L. Smith Yang Wang Yang Wang Kirk Rowley Kirk Rowley Donna M. Ambrosino Donna M. Ambrosino Phillip D. Zamore Phillip D. Zamore Brian G. Pierce Brian G. Pierce Deborah C. Molrine Deborah C. Molrine Zhiping Weng Zhiping Weng Positions in E1/E2 sequence that show the most significant changes in response to antibody treatment. Public Library of Science 2014 Computational biology Evolutionary biology Organismal evolution Microbial evolution Viral evolution microbiology Virology Viral transmission and infection Viral clearance Viral immune evasion Gastroenterology and hepatology Liver diseases Infectious hepatitis antibody 2014-06-23 02:55:43 Figure https://plos.figshare.com/articles/figure/_Positions_in_E1_E2_sequence_that_show_the_most_significant_changes_in_response_to_antibody_treatment_/1067496 <p><b>Left</b>: Median-shifted chi-square statistic values of the top 15 amino acid positions across E1 and E2 that show the most difference in average chi-square statistic between MBL-HCV1- and placebo-treated subjects. Placebo subject J was unable to be analyzed due to post-rebound viral titers <10,000 IU/ml. The chi-square statistic quantifies changes in amino acid distributions between day 0 and day of rebound for each subject in each position across the genome. A higher statistic represents a larger change in the amino acid distribution (darker red in heatmap). Positions labeled in green are those within the MBL-HCV1 epitope. Positions labeled in blue are known to participate in CD81 binding. Positions in pink belong to the E1 sequence. <b>Right</b>: Differences in mean chi-square statistic between MBL-HCV1-treated and placebo patients. Note that change in position 415 is most significant being 10-fold higher than the second-ranked position 417.</p>