10.1371/journal.pone.0100325.g003
Gregory J. Babcock
Gregory
J. Babcock
Sowmya Iyer
Sowmya
Iyer
Heidi L. Smith
Heidi
L. Smith
Yang Wang
Yang
Wang
Kirk Rowley
Kirk
Rowley
Donna M. Ambrosino
Donna
M. Ambrosino
Phillip D. Zamore
Phillip
D. Zamore
Brian G. Pierce
Brian G.
Pierce
Deborah C. Molrine
Deborah
C. Molrine
Zhiping Weng
Zhiping
Weng
Positions in E1/E2 sequence that show the most significant changes in response to antibody treatment.
Public Library of Science
2014
Computational biology
Evolutionary biology
Organismal evolution
Microbial evolution
Viral evolution
microbiology
Virology
Viral transmission and infection
Viral clearance
Viral immune evasion
Gastroenterology and hepatology
Liver diseases
Infectious hepatitis
antibody
2014-06-23 02:55:43
Figure
https://plos.figshare.com/articles/figure/_Positions_in_E1_E2_sequence_that_show_the_most_significant_changes_in_response_to_antibody_treatment_/1067496
<p><b>Left</b>: Median-shifted chi-square statistic values of the top 15 amino acid positions across E1 and E2 that show the most difference in average chi-square statistic between MBL-HCV1- and placebo-treated subjects. Placebo subject J was unable to be analyzed due to post-rebound viral titers <10,000 IU/ml. The chi-square statistic quantifies changes in amino acid distributions between day 0 and day of rebound for each subject in each position across the genome. A higher statistic represents a larger change in the amino acid distribution (darker red in heatmap). Positions labeled in green are those within the MBL-HCV1 epitope. Positions labeled in blue are known to participate in CD81 binding. Positions in pink belong to the E1 sequence. <b>Right</b>: Differences in mean chi-square statistic between MBL-HCV1-treated and placebo patients. Note that change in position 415 is most significant being 10-fold higher than the second-ranked position 417.</p>