10.1371/journal.pgen.1004423.g002 John P. Kemp John P. Kemp Carolina Medina-Gomez Carolina Medina-Gomez Karol Estrada Karol Estrada Beate St Pourcain Beate St Pourcain Denise H. M. Heppe Denise H. M. Heppe Nicole M. Warrington Nicole M. Warrington Ling Oei Ling Oei Susan M. Ring Susan M. Ring Claudia J. Kruithof Claudia J. Kruithof Nicholas J. Timpson Nicholas J. Timpson Lisa E. Wolber Lisa E. Wolber Sjur Reppe Sjur Reppe Kaare Gautvik Kaare Gautvik Elin Grundberg Elin Grundberg Bing Ge Bing Ge Bram van der Eerden Bram van der Eerden Jeroen van de Peppel Jeroen van de Peppel Matthew A. Hibbs Matthew A. Hibbs Cheryl L. Ackert-Bicknell Cheryl L. Ackert-Bicknell Kwangbom Choi Kwangbom Choi Daniel L. Koller Daniel L. Koller Michael J. Econs Michael J. Econs Frances M. K. Williams Frances M. K. Williams Tatiana Foroud Tatiana Foroud M. Carola Zillikens M. Carola Zillikens Claes Ohlsson Claes Ohlsson Albert Hofman Albert Hofman André G. Uitterlinden André G. Uitterlinden George Davey Smith George Davey Smith Vincent W. V. Jaddoe Vincent W. V. Jaddoe Jonathan H. Tobias Jonathan H. Tobias Fernando Rivadeneira Fernando Rivadeneira David M. Evans David M. Evans Regional association plots of the top skull- and upper limb-BMD associated SNPs at the 6q22.32 locus before and after conditioning on published SNP (rs13204965*) in addition to a comparison of the effect sizes of the top skull- (rs2130604) and upper limb-BMD (rs1262476) associated SNP (before conditional analysis) on BMD at three different skeletal sites. Public Library of Science 2014 Biochemistry metabolism Bone and mineral metabolism Computational biology genome analysis Genome-wide association studies genetics Human genetics rheumatology skull- limb-bmd snps locus conditioning published snp sizes conditional bmd skeletal 2014-06-19 03:23:17 Figure https://plos.figshare.com/articles/figure/_Regional_association_plots_of_the_top_skull_and_upper_limb_BMD_associated_SNPs_at_the_6q22_32_locus_before_and_after_conditioning_on_published_SNP_rs13204965_in_addition_to_a_comparison_of_the_effect_sizes_of_the_top_skull_rs2130604_and_upper_limb_BMD_rs/1062654 <p>For I and II: Circles show GWA meta-analysis <i>P</i>-values and positions of SNPs found within each locus. Top SNPs are denoted by diamonds. Different colours indicate varying degrees of pairwise linkage disequilibrium (HapMap 2 CEPH) between the top SNP and all other SNPs. Blue vertical shaded areas indicate the position of rs2130604 (top SNP A-I) and rs1262476 (top SNP B-I) for each analysis. The red vertical shaded area represents the position of the published SNP (rs13204965*). Rsids of relevant SNPs (blue dots) have been provided. For III: The per allele effect in SD (red dot) and 95% confidence intervals (error bar) of each top SNP (before conditional analysis) for lower limb (LL), upper limb (UL) and skull (SK) BMD are plotted with their specific strength of evidence against the null hypothesis of no association. Please note: <i>RSPO3</i> is also found in the 6q.22.32 locus containing <i>CENPW</i>.</p>