10.1371/journal.pgen.1004423.g002
John P. Kemp
John
P. Kemp
Carolina Medina-Gomez
Carolina
Medina-Gomez
Karol Estrada
Karol
Estrada
Beate St Pourcain
Beate
St Pourcain
Denise H. M. Heppe
Denise
H. M. Heppe
Nicole M. Warrington
Nicole
M. Warrington
Ling Oei
Ling
Oei
Susan M. Ring
Susan
M. Ring
Claudia J. Kruithof
Claudia
J. Kruithof
Nicholas J. Timpson
Nicholas
J. Timpson
Lisa E. Wolber
Lisa
E. Wolber
Sjur Reppe
Sjur
Reppe
Kaare Gautvik
Kaare
Gautvik
Elin Grundberg
Elin
Grundberg
Bing Ge
Bing
Ge
Bram van der Eerden
Bram
van der Eerden
Jeroen van de Peppel
Jeroen
van de Peppel
Matthew A. Hibbs
Matthew
A. Hibbs
Cheryl L. Ackert-Bicknell
Cheryl
L. Ackert-Bicknell
Kwangbom Choi
Kwangbom
Choi
Daniel L. Koller
Daniel
L. Koller
Michael J. Econs
Michael
J. Econs
Frances M. K. Williams
Frances
M. K. Williams
Tatiana Foroud
Tatiana
Foroud
M. Carola Zillikens
M.
Carola Zillikens
Claes Ohlsson
Claes
Ohlsson
Albert Hofman
Albert
Hofman
André G. Uitterlinden
André
G. Uitterlinden
George Davey Smith
George
Davey Smith
Vincent W. V. Jaddoe
Vincent
W. V. Jaddoe
Jonathan H. Tobias
Jonathan
H. Tobias
Fernando Rivadeneira
Fernando
Rivadeneira
David M. Evans
David
M. Evans
Regional association plots of the top skull- and upper limb-BMD associated SNPs at the 6q22.32 locus before and after conditioning on published SNP (rs13204965*) in addition to a comparison of the effect sizes of the top skull- (rs2130604) and upper limb-BMD (rs1262476) associated SNP (before conditional analysis) on BMD at three different skeletal sites.
Public Library of Science
2014
Biochemistry
metabolism
Bone and mineral metabolism
Computational biology
genome analysis
Genome-wide association studies
genetics
Human genetics
rheumatology
skull-
limb-bmd
snps
locus
conditioning
published
snp
sizes
conditional
bmd
skeletal
2014-06-19 03:23:17
Figure
https://plos.figshare.com/articles/figure/_Regional_association_plots_of_the_top_skull_and_upper_limb_BMD_associated_SNPs_at_the_6q22_32_locus_before_and_after_conditioning_on_published_SNP_rs13204965_in_addition_to_a_comparison_of_the_effect_sizes_of_the_top_skull_rs2130604_and_upper_limb_BMD_rs/1062654
<p>For I and II: Circles show GWA meta-analysis <i>P</i>-values and positions of SNPs found within each locus. Top SNPs are denoted by diamonds. Different colours indicate varying degrees of pairwise linkage disequilibrium (HapMap 2 CEPH) between the top SNP and all other SNPs. Blue vertical shaded areas indicate the position of rs2130604 (top SNP A-I) and rs1262476 (top SNP B-I) for each analysis. The red vertical shaded area represents the position of the published SNP (rs13204965*). Rsids of relevant SNPs (blue dots) have been provided. For III: The per allele effect in SD (red dot) and 95% confidence intervals (error bar) of each top SNP (before conditional analysis) for lower limb (LL), upper limb (UL) and skull (SK) BMD are plotted with their specific strength of evidence against the null hypothesis of no association. Please note: <i>RSPO3</i> is also found in the 6q.22.32 locus containing <i>CENPW</i>.</p>