Genomic context of cis-regulated allele-specific methylation events.
John N. Hutchinson
Towfique Raj
Jes Fagerness
Eli Stahl
Fernando T. Viloria
Alexander Gimelbrant
Johanna Seddon
Mark Daly
Andrew Chess
Robert Plenge
10.1371/journal.pone.0098464.g004
https://plos.figshare.com/articles/figure/_Genomic_context_of_cis_regulated_allele_specific_methylation_events_/1050820
<p>Illustrations showing genomic context and individual CpG methylation levels at three separate MPRs (rs10491434 (left), rs6569648 (middle) and rs943049 (right)). The chromosomal location of each amplicon is demonstrated with an ideogram. and the RefSeq genes (orange) surrounding the amplicon (red line) shown below. A section (grey box) contracts to the amplicon region itself to show the relative positions of the SNPs (black lines) and CpGs (blue lines) within the amplicons themselves (red bars); methylation levels of the alternate (grey circles) and reference (yellow circles) alleles within samples heterozygous for the SNP are graphed below each CpG. Asterixes (*) mark the CpGs illustrated within <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0098464#pone-0098464-g003" target="_blank">Figure 3</a>.</p>
2014-06-09 02:58:04
Biochemistry
dna
DNA modification
Computational biology
genome analysis
Genome-wide association studies
genetics
gene expression
Gene regulation
genomics
Functional genomics
Human genetics
Genetic association studies
epigenetics
Genetics of disease
immunology
Clinical immunology
Autoimmune diseases
Genetics of the immune system
cis-regulated
allele-specific
methylation