10.1371/journal.pone.0098165.g005 Nicholas S. Kirkby Nicholas S. Kirkby Martina H. Lundberg Martina H. Lundberg William R. Wright William R. Wright Timothy D. Warner Timothy D. Warner Mark J. Paul-Clark Mark J. Paul-Clark Jane A. Mitchell Jane A. Mitchell COX-2 deletion increases circulating levels of lymphocytes and lymphocyte-related cytokines in fat-fed apoE<sup>−/−</sup> mice. Public Library of Science 2014 Computational biology immunology cardiology Cardiovascular pharmacology Clinical medicine deletion circulating lymphocytes lymphocyte-related cytokines fat-fed 2014-06-02 04:41:35 Figure https://plos.figshare.com/articles/figure/_COX_2_deletion_increases_circulating_levels_of_lymphocytes_and_lymphocyte_related_cytokines_in_fat_fed_apoE_8722_8722_mice_/1042661 <p>Measurement of plasma levels of cytokines by multiplex immunoassay (a) demonstrated an increased in the lymphocyte-related cytokines IL-2 and IL-12 (total) and the neutrophil chemoattractant KC, but no change in levels of TNFα, IL-1β, IL-4, IL-10 or IFNγ. Cell counts in whole blood (b), measured in parallel, indicated an increase in circulating lymphocytes, but not monocytes, neutrophils or eosinophils. *; p<0.05 vs apoE<sup>−/−</sup>/COX-2<sup>+/+</sup> by unpaired t-test; n = 10–25.</p>