%0 Figure %A T. Koivumäki, Jussi %A Seemann, Gunnar %A M. Maleckar, Mary %A Tavi, Pasi %D 2014 %T Effect of individual remodeling targets on CaT and AP characteristics in cAF. %U https://plos.figshare.com/articles/figure/_Effect_of_individual_remodeling_targets_on_CaT_and_AP_characteristics_in_cAF_/1034692 %R 10.1371/journal.pcbi.1003620.g003 %2 https://plos.figshare.com/ndownloader/files/1508318 %K physics %K remodeling %K targets %K ap %X

(A) normal sinus rhythm (nSR). (B) chronic atrial fibrillation (cAF: all). (C–F) four remodeled cellular components separately (L-type Ca2+ current, ICaL; inward rectified K+ current, IK1; Na+/Ca2+ exchanger current, INCX; and increased cell volume, dilation), respectively. Columns from left to right: action potential (AP), Ca2+ transient (CaT) averaged over cell volume, and spatiotemporal presentation of CaT (x =  distance from sarcolemma). Colour scale for right column: 0–1.5 µM corresponds to dark blue – dark red (similar to Figure 1 F&G). All results are obtained at BCL = 1000 ms.

%I PLOS Computational Biology