Ma, Jin J. Chadban, Steven Y. Zhao, Cathy Chen, Xiaochen Kwan, Tony Panchapakesan, Usha Pollock, Carol A. Wu, Huiling TLR4 deficiency suppressed inflammatory and fibrotic responses in diabetic kidney. <p>The expression of endogenous TLR ligands was upregulated in WT-DN kidneys and TLR4<sup>−/−</sup>diabetic kidneys at week 6 compared with WT non-diabetic controls. (A). Gene expression of IL-6 (A), TNF-α (B), CCL2 (C), CXCL10 (D), TGF-β (E) and fibronectin (F) were upregulated in WT mice with diabetes, but suppressed in TLR4<sup>−/−</sup> mice with diabetes, as measured by RT-PCR. Data are presented as means ± SD; ** <i>p</i><0.01; *** <i>p</i><0.001. The number of animals per group was described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0097985#pone-0097985-g001" target="_blank">Figure 1</a>.</p> cell biology;Signal transduction;cell signaling;Membrane receptor signaling;Immune receptor signaling;Immunological signaling;Molecular cell biology;Metabolic disorders;Diabetes mellitus;Type 1 diabetes;type 2 diabetes;Nephrology;Chronic kidney disease;Model organisms;Animal models;Mouse models;deficiency;suppressed;inflammatory;fibrotic;responses;diabetic 2014-05-19
    https://plos.figshare.com/articles/figure/_TLR4_deficiency_suppressed_inflammatory_and_fibrotic_responses_in_diabetic_kidney_/1031192
10.1371/journal.pone.0097985.g007