TLR4 deficiency suppressed inflammatory and fibrotic responses in diabetic kidney.
Jin Ma
Steven J. Chadban
Cathy Y. Zhao
Xiaochen Chen
Tony Kwan
Usha Panchapakesan
Carol A. Pollock
Huiling Wu
10.1371/journal.pone.0097985.g007
https://plos.figshare.com/articles/figure/_TLR4_deficiency_suppressed_inflammatory_and_fibrotic_responses_in_diabetic_kidney_/1031192
<p>The expression of endogenous TLR ligands was upregulated in WT-DN kidneys and TLR4<sup>−/−</sup>diabetic kidneys at week 6 compared with WT non-diabetic controls. (A). Gene expression of IL-6 (A), TNF-α (B), CCL2 (C), CXCL10 (D), TGF-β (E) and fibronectin (F) were upregulated in WT mice with diabetes, but suppressed in TLR4<sup>−/−</sup> mice with diabetes, as measured by RT-PCR. Data are presented as means ± SD; ** <i>p</i><0.01; *** <i>p</i><0.001. The number of animals per group was described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0097985#pone-0097985-g001" target="_blank">Figure 1</a>.</p>
2014-05-19 03:23:24
cell biology
Signal transduction
cell signaling
Membrane receptor signaling
Immune receptor signaling
Immunological signaling
Molecular cell biology
Metabolic disorders
Diabetes mellitus
Type 1 diabetes
type 2 diabetes
Nephrology
Chronic kidney disease
Model organisms
Animal models
Mouse models
deficiency
suppressed
inflammatory
fibrotic
responses
diabetic