TLR4 deficiency reduced macrophage accumulation in diabetic nephropathy.
Jin Ma
Steven J. Chadban
Cathy Y. Zhao
Xiaochen Chen
Tony Kwan
Usha Panchapakesan
Carol A. Pollock
Huiling Wu
10.1371/journal.pone.0097985.g006
https://plos.figshare.com/articles/figure/_TLR4_deficiency_reduced_macrophage_accumulation_in_diabetic_nephropathy_/1031191
<p>Macrophage (CD68<sup>+</sup> or F8/40<sup>+</sup>) accumulation was evident in WT mice with diabetes, but prevented by TLR4 deficiency in both the interstitial (A) and glomerular (B & C) compartments. Data are present as means ± SEM; * <i>p</i><0.05; *** <i>p</i><0.001.</p>
2014-05-19 03:23:24
cell biology
Signal transduction
cell signaling
Membrane receptor signaling
Immune receptor signaling
Immunological signaling
Molecular cell biology
Metabolic disorders
Diabetes mellitus
Type 1 diabetes
type 2 diabetes
Nephrology
Chronic kidney disease
Model organisms
Animal models
Mouse models
deficiency
reduced
macrophage
accumulation
diabetic