TLR4 deficiency reduced macrophage accumulation in diabetic nephropathy. Jin Ma Steven J. Chadban Cathy Y. Zhao Xiaochen Chen Tony Kwan Usha Panchapakesan Carol A. Pollock Huiling Wu 10.1371/journal.pone.0097985.g006 https://plos.figshare.com/articles/figure/_TLR4_deficiency_reduced_macrophage_accumulation_in_diabetic_nephropathy_/1031191 <p>Macrophage (CD68<sup>+</sup> or F8/40<sup>+</sup>) accumulation was evident in WT mice with diabetes, but prevented by TLR4 deficiency in both the interstitial (A) and glomerular (B & C) compartments. Data are present as means ± SEM; * <i>p</i><0.05; *** <i>p</i><0.001.</p> 2014-05-19 03:23:24 cell biology Signal transduction cell signaling Membrane receptor signaling Immune receptor signaling Immunological signaling Molecular cell biology Metabolic disorders Diabetes mellitus Type 1 diabetes type 2 diabetes Nephrology Chronic kidney disease Model organisms Animal models Mouse models deficiency reduced macrophage accumulation diabetic