%0 Figure %A Ma, Jin %A J. Chadban, Steven %A Y. Zhao, Cathy %A Chen, Xiaochen %A Kwan, Tony %A Panchapakesan, Usha %A Pollock, Carol A. %A Wu, Huiling %D 2014 %T TLR4 deficiency protected diabetic kidneys from interstitial fibrosis and tubular injury. %U https://plos.figshare.com/articles/figure/_TLR4_deficiency_protected_diabetic_kidneys_from_interstitial_fibrosis_and_tubular_injury_/1031190 %R 10.1371/journal.pone.0097985.g005 %2 https://plos.figshare.com/ndownloader/files/1503470 %K cell biology %K Signal transduction %K cell signaling %K Membrane receptor signaling %K Immune receptor signaling %K Immunological signaling %K Molecular cell biology %K Metabolic disorders %K Diabetes mellitus %K Type 1 diabetes %K type 2 diabetes %K Nephrology %K Chronic kidney disease %K Model organisms %K Animal models %K Mouse models %K deficiency %K protected %K diabetic %K kidneys %K interstitial %K fibrosis %K tubular %X

(A) Significant interstitial collagen accumulation was evident in WT but not TLR4−/− mice with diabetes at 12 and 24 weeks. (B) Illustration of representative sections of the histological changes on PSR staining for collagen. (C) Immunohistochemical staining showed upregulation of α-SMA in WT, but not TLR4−/− mice, with diabetes as compared to non-diabetic controls at week 24. (D) Significant upregulation of KIM-1 was apparent in WT mice with diabetes, but attenuated in TLR4−/− diabetic kidneys. The data are present as the means ± SEM; * p<0.05; ** p<0.01; *** p<0.001. The number of animals per group was described in Figure 1.

%I PLOS ONE