TEL effect on glucose disposal and bone structure. Vipula Kolli Lance A. Stechschulte Abigail R. Dowling Sima Rahman Piotr J. Czernik Beata Lecka-Czernik 10.1371/journal.pone.0096323.g006 https://plos.figshare.com/articles/figure/_TEL_effect_on_glucose_disposal_and_bone_structure_/1020127 <p>A. Effect of 4 days administration of either regular diet (open circles), or diet supplemented with 1.5 mg/kg/d TEL (open triangles), or 3 mg/kg/d TEL (black triangles), or 20 mg/kg/d ROSI (open squares), on glucose tolerance of A<sup>vy</sup>/a mice measured with introperitoneal glucose tolerance test (IGTT), as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0096323#s2" target="_blank">Material and Methods</a> (n = 4 animals per group). B. Glucose disposal measured with IGTT in DIO mice at the end of 4 wks administration of either non-supplemented HFD (open circles), or HFD supplemented with 3 mg/kg/d TEL (black triangles), or with 20 mg/kg/d ROSI (open squares) (n = 8 animals per group). C. mCT analysis of L4 vertebra trabecular bone of A<sup>vy</sup>/a mice after 4 wks administration of either control non-supplemented diet (C), or chow supplemented with 20 mg/kg/d ROSI (R), or drinking water supplemented with 3 mg/kg/d TEL (T). BV/TV – bone volume fraction in the region of interest (ROI) (%); Tb.N. – average number of trabeculae per unit length (1/mm) of ROI; Tb.Th. – trabecular thickness (mm); Tb.Sp. – trabecular separation representing mean distance between trabeculae (mm). D. Number of adipocytes in proximal tibia of experimental animals (n = 4 per group). C – control; R – ROSI; T – TEL. * p<0.05 <i>vs</i>. control.</p> 2014-05-08 02:55:13 anatomy biological tissue Connective tissue bone Musculoskeletal system Biochemistry metabolism Energy metabolism physiology Physiological processes Endocrinology Diabetic endocrinology Metabolic disorders Diabetes mellitus type 2 diabetes glucose disposal