Saint-Geniez, Magali Ghelfi, Elisa Liang, Xiaoliang Yu, Chenwei Spencer, Carrie Abend, Stephanie Hotamisligil, Gokhan Cataltepe, Sule Specific localization of FABP4 in neovascular endothelial cells. <p>(A) Confocal imaging of neovascular tufts in P17 WT OIR retina flat-mount following immunostaining for FABP4 (red), EC-specific marker EMCN (green), activated microglia-specific marker Iba1 (white) and DAPI (blue). FABP4 is strongly associated with the neovascular tufts and absent from the normal vasculature. FABP4 was not detected in the Iba1- positive cells but co-localized with EMCN-positive cells. (B) Immunostaining of FABP4 (red) EMCN (green) and DAPI (blue) in a large neovascular structure followed by confocal sectioning confirmed FABP4 localization to ECs of pathological neovessels. Scale bar is 50 µm.</p> anatomy;biological tissue;epithelium;Epithelial cells;Endothelial cells;Cardiovascular anatomy;Biochemistry;lipids;cell biology;Cellular types;Molecular cell biology;developmental biology;Organism development;genetics;gene expression;cardiology;ophthalmology;Retinal disorders;pediatrics;Child development;localization;fabp4;neovascular;endothelial 2014-05-06
    https://plos.figshare.com/articles/figure/_Specific_localization_of_FABP4_in_neovascular_endothelial_cells_/1017627
10.1371/journal.pone.0096253.g003