10.1371/journal.pone.0096253.g003
Magali Saint-Geniez
Magali
Saint-Geniez
Elisa Ghelfi
Elisa
Ghelfi
Xiaoliang Liang
Xiaoliang
Liang
Chenwei Yu
Chenwei
Yu
Carrie Spencer
Carrie
Spencer
Stephanie Abend
Stephanie
Abend
Gokhan Hotamisligil
Gokhan
Hotamisligil
Sule Cataltepe
Sule
Cataltepe
Specific localization of FABP4 in neovascular endothelial cells.
Public Library of Science
2014
anatomy
biological tissue
epithelium
Epithelial cells
Endothelial cells
Cardiovascular anatomy
Biochemistry
lipids
cell biology
Cellular types
Molecular cell biology
developmental biology
Organism development
genetics
gene expression
cardiology
ophthalmology
Retinal disorders
pediatrics
Child development
localization
fabp4
neovascular
endothelial
2014-05-06 02:57:11
Figure
https://plos.figshare.com/articles/figure/_Specific_localization_of_FABP4_in_neovascular_endothelial_cells_/1017627
<p>(A) Confocal imaging of neovascular tufts in P17 WT OIR retina flat-mount following immunostaining for FABP4 (red), EC-specific marker EMCN (green), activated microglia-specific marker Iba1 (white) and DAPI (blue). FABP4 is strongly associated with the neovascular tufts and absent from the normal vasculature. FABP4 was not detected in the Iba1- positive cells but co-localized with EMCN-positive cells. (B) Immunostaining of FABP4 (red) EMCN (green) and DAPI (blue) in a large neovascular structure followed by confocal sectioning confirmed FABP4 localization to ECs of pathological neovessels. Scale bar is 50 µm.</p>