10.1371/journal.pgen.1004290.g005
Roberta L. Hannibal
Roberta
L. Hannibal
Edward B. Chuong
Edward
B. Chuong
Juan Carlos Rivera-Mulia
Juan
Carlos Rivera-Mulia
David M. Gilbert
David
M. Gilbert
Anton Valouev
Anton
Valouev
Julie C. Baker
Julie
C. Baker
UR domains are heterochromatic.
Public Library of Science
2014
cell biology
Chromosome biology
chromosomes
Chromosome structure and function
chromatin
developmental biology
Cell differentiation
genetics
epigenetics
Histone modification
genomics
Structural genomics
gene expression
domains
2014-05-01 03:35:31
Figure
https://plos.figshare.com/articles/figure/_UR_domains_are_heterochromatic_/1013499
<p><b>A</b>. UR domains correlate with histone marks. Screen shot from the UCSC genome browser of the last half of chromosome 14 (schematic shown above screen shot) showing the following: 3SEQ from <i>in vivo</i> e9.5 TGCs and <i>in vitro</i> d7 TGCs (black), active histone marks (H3K27ac, H3K4me1, H3K4me3; dark purple) and repressive histone marks (H3K9me3, H3K27me3; orange) for cultured TS cells and TGCs, and aCGH and WGS data from <i>in vivo</i> e9.5 TGCs (pink/red). Histone mark mean is darker color, maximum is lighter color. UR domains boxed in pink. <b>B</b>. UR domains are a subset of heterochromatin in TS cells. The Pearson correlation (R) between NLog2 values of TGC vs. embryo (WGS) and fold enrichment (FE) for histone marks. Data points represent 1 Mb windows in the genome. UR domains (negative NLog2 values) are correlated with high values for repressive histone marks (negative R values). UR domains (negative NLog2 values) are negatively correlated with high values for active histone marks (positive R values). Red lines represent the lowess line (locally weighted scatterplot smoothing) of the data points. UR domains boxed in pink. <b>C</b>. UR domains are a subset of heterochromatin in TGCs. See (<b>B</b>) for plot details.</p>