10.1371/journal.pgen.1004290.g005 Roberta L. Hannibal Roberta L. Hannibal Edward B. Chuong Edward B. Chuong Juan Carlos Rivera-Mulia Juan Carlos Rivera-Mulia David M. Gilbert David M. Gilbert Anton Valouev Anton Valouev Julie C. Baker Julie C. Baker UR domains are heterochromatic. Public Library of Science 2014 cell biology Chromosome biology chromosomes Chromosome structure and function chromatin developmental biology Cell differentiation genetics epigenetics Histone modification genomics Structural genomics gene expression domains 2014-05-01 03:35:31 Figure https://plos.figshare.com/articles/figure/_UR_domains_are_heterochromatic_/1013499 <p><b>A</b>. UR domains correlate with histone marks. Screen shot from the UCSC genome browser of the last half of chromosome 14 (schematic shown above screen shot) showing the following: 3SEQ from <i>in vivo</i> e9.5 TGCs and <i>in vitro</i> d7 TGCs (black), active histone marks (H3K27ac, H3K4me1, H3K4me3; dark purple) and repressive histone marks (H3K9me3, H3K27me3; orange) for cultured TS cells and TGCs, and aCGH and WGS data from <i>in vivo</i> e9.5 TGCs (pink/red). Histone mark mean is darker color, maximum is lighter color. UR domains boxed in pink. <b>B</b>. UR domains are a subset of heterochromatin in TS cells. The Pearson correlation (R) between NLog2 values of TGC vs. embryo (WGS) and fold enrichment (FE) for histone marks. Data points represent 1 Mb windows in the genome. UR domains (negative NLog2 values) are correlated with high values for repressive histone marks (negative R values). UR domains (negative NLog2 values) are negatively correlated with high values for active histone marks (positive R values). Red lines represent the lowess line (locally weighted scatterplot smoothing) of the data points. UR domains boxed in pink. <b>C</b>. UR domains are a subset of heterochromatin in TGCs. See (<b>B</b>) for plot details.</p>