10.1371/journal.pgen.1004290.g001
Roberta L. Hannibal
Roberta
L. Hannibal
Edward B. Chuong
Edward
B. Chuong
Juan Carlos Rivera-Mulia
Juan
Carlos Rivera-Mulia
David M. Gilbert
David
M. Gilbert
Anton Valouev
Anton
Valouev
Julie C. Baker
Julie
C. Baker
UR domains are specific to TGCs.
Public Library of Science
2014
cell biology
Chromosome biology
chromosomes
Chromosome structure and function
chromatin
developmental biology
Cell differentiation
genetics
epigenetics
Histone modification
genomics
Structural genomics
gene expression
domains
2014-05-01 03:35:31
Figure
https://plos.figshare.com/articles/figure/_UR_domains_are_specific_to_TGCs_/1013492
<p><b>A</b>. TGCs in relationship to other embryonic and maternal tissues at embryonic day 9.5. Left: schematic of e9.5 conceptus. Yellow: parietal TGCs; gray: other embryonic/extraembryonic tissue; pink: maternal decidua. Right: confocal images of TGCs and embryonic cells (somites) stained for DAPI (blue) to show nuclear size. Scale bar = 75 µm. <b>B</b>. Location and reproducibility of UR domains on the autosomes of e9.5 TGCs. Summary of results from both biological replicates of e9.5 TGC vs. embryo aCGH (FDR = 0.0001). Darker green/longer bars (asterisks) indicate UR domains present in both replicates. <b>C</b>. UR domains are specific to TGCs. Plot comparing position along chromosome 14, a representative chromosome, to the normalized log 2 ratio (NLog2 Ratio) of array intensity of test vs. control. Red: e9.5 TGC vs. embryo; purple: placenta vs. embryo; blue: megakaryocyte vs. embryo. Two biological replicates are plotted for each cell type. Dashed line: FDR = 0.0001. All autosomes shown in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004290#pgen.1004290.s002" target="_blank">Figure S2</a>.</p>