10.1371/journal.pgen.1004290.g001 Roberta L. Hannibal Roberta L. Hannibal Edward B. Chuong Edward B. Chuong Juan Carlos Rivera-Mulia Juan Carlos Rivera-Mulia David M. Gilbert David M. Gilbert Anton Valouev Anton Valouev Julie C. Baker Julie C. Baker UR domains are specific to TGCs. Public Library of Science 2014 cell biology Chromosome biology chromosomes Chromosome structure and function chromatin developmental biology Cell differentiation genetics epigenetics Histone modification genomics Structural genomics gene expression domains 2014-05-01 03:35:31 Figure https://plos.figshare.com/articles/figure/_UR_domains_are_specific_to_TGCs_/1013492 <p><b>A</b>. TGCs in relationship to other embryonic and maternal tissues at embryonic day 9.5. Left: schematic of e9.5 conceptus. Yellow: parietal TGCs; gray: other embryonic/extraembryonic tissue; pink: maternal decidua. Right: confocal images of TGCs and embryonic cells (somites) stained for DAPI (blue) to show nuclear size. Scale bar = 75 µm. <b>B</b>. Location and reproducibility of UR domains on the autosomes of e9.5 TGCs. Summary of results from both biological replicates of e9.5 TGC vs. embryo aCGH (FDR = 0.0001). Darker green/longer bars (asterisks) indicate UR domains present in both replicates. <b>C</b>. UR domains are specific to TGCs. Plot comparing position along chromosome 14, a representative chromosome, to the normalized log 2 ratio (NLog2 Ratio) of array intensity of test vs. control. Red: e9.5 TGC vs. embryo; purple: placenta vs. embryo; blue: megakaryocyte vs. embryo. Two biological replicates are plotted for each cell type. Dashed line: FDR = 0.0001. All autosomes shown in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004290#pgen.1004290.s002" target="_blank">Figure S2</a>.</p>