10.1371/journal.pone.0095392.g003 Arjen J. Boender Arjen J. Boender Johannes W. de Jong Johannes W. de Jong Linde Boekhoudt Linde Boekhoudt Mieneke C. M. Luijendijk Mieneke C. M. Luijendijk Geoffrey van der Plasse Geoffrey van der Plasse Roger A. H. Adan Roger A. H. Adan The effect of CNO on PR-performance is dose-dependently suppressed by a DRD1-antagonist. Public Library of Science 2014 Biochemistry Neurochemistry neuromodulation neurotransmitters neuroscience Behavioral neuroscience Neuroethology Specimen preparation and treatment Mechanical treatment of specimens Specimen disruption electroporation cno pr-performance dose-dependently suppressed 2014-04-15 04:31:32 Figure https://plos.figshare.com/articles/figure/_The_effect_of_CNO_on_PR_performance_is_dose_dependently_suppressed_by_a_DRD1_antagonist_/1000578 <p>(A) In seven animals cannulae were correctly placed in the nucleus accumbens (Acb). The outlined numbers represent the location of the ending of the guide cannulae, for each animal (1–8) individually. Abbreviations: AcbC = nucleus accumbens core, AcbSh = nucleus accumbens shell, CPu = caudate putamen. (B) Representative image (animal 5) of cannula placement in the Acb. The horizontal arrow indicates the ending of the cannula (C) Intra-Acb infusions of the D1-antagonist SCH22390 dose-dependently suppressed CNO-induced increases in the number of active lever presses. Data are depicted with bars representing group means+SEM, with * indicating a significant difference of i.p. CNO vs. i.p. saline of p<0.05 and & indicating a significant difference of intra-Acb SCH23390 vs. intra-Acb saline of p<0.05.</p>