10.1371/journal.pone.0095392.g003
Arjen J. Boender
Arjen J.
Boender
Johannes W. de Jong
Johannes
W. de Jong
Linde Boekhoudt
Linde
Boekhoudt
Mieneke C. M. Luijendijk
Mieneke
C. M. Luijendijk
Geoffrey van der Plasse
Geoffrey
van der Plasse
Roger A. H. Adan
Roger
A. H. Adan
The effect of CNO on PR-performance is dose-dependently suppressed by a DRD1-antagonist.
Public Library of Science
2014
Biochemistry
Neurochemistry
neuromodulation
neurotransmitters
neuroscience
Behavioral neuroscience
Neuroethology
Specimen preparation and treatment
Mechanical treatment of specimens
Specimen disruption
electroporation
cno
pr-performance
dose-dependently
suppressed
2014-04-15 04:31:32
Figure
https://plos.figshare.com/articles/figure/_The_effect_of_CNO_on_PR_performance_is_dose_dependently_suppressed_by_a_DRD1_antagonist_/1000578
<p>(A) In seven animals cannulae were correctly placed in the nucleus accumbens (Acb). The outlined numbers represent the location of the ending of the guide cannulae, for each animal (1–8) individually. Abbreviations: AcbC = nucleus accumbens core, AcbSh = nucleus accumbens shell, CPu = caudate putamen. (B) Representative image (animal 5) of cannula placement in the Acb. The horizontal arrow indicates the ending of the cannula (C) Intra-Acb infusions of the D1-antagonist SCH22390 dose-dependently suppressed CNO-induced increases in the number of active lever presses. Data are depicted with bars representing group means+SEM, with * indicating a significant difference of i.p. CNO vs. i.p. saline of p<0.05 and & indicating a significant difference of intra-Acb SCH23390 vs. intra-Acb saline of p<0.05.</p>